S-adenosyl-L-methionine, also known as adenosyl methionine or SAM-e, is a substance naturally produced by the body. Involved in the manufacture of a large number of molecules: hormonesproteins and chemical messengers of the brain, Antioxidants Natural, for example. As a dietary supplement, it is mainly served to relievearthritis and the depression.
| European health authorities’ decision |
|---|
| In 2012, European health authorities (EFSA, the European Food Safety Authority and the European Commission) commented on some of the health claims for dietary supplements containing S-adenosyl-L-methionine (SAM-e). After reviewing the scientific data, they considered that these products cannot Not Claim to help maintain joint health or mobility. This claim of effect is now prohibited for dietary supplements containing S-adenosyl-L-methionine (SAM-e). |
S-adenosyl-L-methionine purported uses and properties
Because blood levels of SAM-e are unusually low in infected people depression, fromarthritis (rheumatism) and liver disease, this substance is marketed to relieve these health problems.
It is also suggested to relieve symptoms fibromyalgia, a health problem that combines fatigue, depression and muscle pain.
How effective is S-adenosyl-L-methionine?
SAM-e is marketed as a drug against arthritis in different European countries. This use is based on several studies involving more than 22,000 people that showed that SAM-e effectively relieves pain associated with:arthritis. Its effects appear after up to five weeks when SAM-e is given in high doses.
In 2012, European health authorities rejected the joint health claim of dietary supplements containing SAM-e. For experts, there is not enough scientific evidence to justify this claim. Thus, dietary supplements containing SAM-e sold in the European Union cannot have any effect on joints.
SAM-e has never been shown to be effective in treating depression. In particular, its potential effects have not been compared with those of Antidepressants used today.
The effectiveness of SAM-e against symptoms subordinate fibromyalgia It has not yet undergone convincing clinical studies.
Some studies have indicated that SAM-e has some value in the management of associated liver disorders alcoholism However, other studies still need to be done to confirm this use.
Precautions to be taken with S-adenosyl-L-methionine
Pregnant and breastfeeding women should refrain from taking SAM-e.
It is also not recommended to use this substance for people who suffer from it bipolar disorders (obsessed depression) or illness Parkinson’s Disease, for those who take Drugs Antidepressants.
It is recommended to take SAM-e with vitamins B6, B9 and B12. This is because taking SAM-e can increase the body’s production of homocysteine, a substance that can be linked to an increased risk of cardiovascular disease and that is best eliminated by those. vitamins.
The side effects From SAM-e the most common are digestive disorder sanxiety, insomnia, muscle cramps;
Origin, Forms and Dosage of S-adenosyl-L-methionine
SAM-e is synthetically manufactured. It is packaged in tablets stomach resistance, that is, that resists gastric juices, often doses of 200 mg.
The doses used in the studies are 400 mg, three times a day for three to five weeks, then 200 mg twice a day. SAM-e appears to be better absorbed when taken on an empty stomach.
People for whom SAM-e causes nausea or digestive disorders At the beginning of treatment, you may increase your dose gradually to avoid this type of side effect.
| Specialist opinion on S-adenosyl-L-methionine |
|---|
| The confusion Prevails over the use of SAM-e in people withar thritis. There is little evidence for the effectiveness of a substance that remains expensive. It should be used in consultation with the attending physician. |
| European health authorities’ decision |
|---|
| In 2012, European health authorities (EFSA, the European Food Safety Authority and the European Commission) commented on some of the health claims for dietary supplements containing S-adenosyl-L-methionine (SAM-e). After reviewing the scientific data, they considered that these products cannot Not Claim to help maintain joint health or mobility. This claim of effect is now prohibited for dietary supplements containing S-adenosyl-L-methionine (SAM-e). |
| Specialist opinion on S-adenosyl-L-methionine |
|---|
| The confusion Prevails over the use of SAM-e in people witharthritis. There is little evidence for the effectiveness of a substance that remains expensive. It should be used in consultation with the attending physician. |